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The BDNF Val66Met polymorphism moderates the relationship between cognitive reserve and executive function

Citation

Ward, D and Summers, MJ and Saunders, NLJ and Ritchie, K and Summers, JJ and Vickers, JC, The BDNF Val66Met polymorphism moderates the relationship between cognitive reserve and executive function, Translational Psychiatry, 5 Article e590. ISSN 2158-3188 (2015) [Refereed Article]


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Licensed under a Creative Commons Attribution 4.0 International License http://creativecommons.org/licenses/ by/4.0/

DOI: doi:10.1038/tp.2015.82

Abstract

The concept of cognitive reserve (CR) has been proposed to account for observed discrepancies between pathology and its clinical manifestation due to underlying differences in brain structure and function. In 433 healthy older adults participating in the Tasmanian Healthy Brain Project, we investigated whether common polymorphic variations in apolipoprotein E (APOE) or brain-derived neurotrophic factor (BDNF) influenced the association between CR contributors and cognitive function in older adults. We show that BDNF Val66Met moderates the association between CR and executive function. CR accounted for 8.5% of the variance in executive function in BDNF Val homozygotes, but CR was a nonsignificant predictor in BDNF Met carriers. APOE polymorphisms were not linked to the influence of CR on cognitive function. This result implicates BDNF in having an important role in capacity for building or accessing CR.

Item Details

Item Type:Refereed Article
Keywords:cognitive reserve, ageing, executive function, BDNF
Research Division:Psychology and Cognitive Sciences
Research Group:Psychology
Research Field:Biological Psychology (Neuropsychology, Psychopharmacology, Physiological Psychology)
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Neurodegenerative Disorders Related to Ageing
Author:Ward, D (Mr David Ward)
Author:Summers, MJ (Dr Mathew Summers)
Author:Saunders, NLJ (Dr Nichole Saunders)
Author:Summers, JJ (Professor Jeffery Summers)
Author:Vickers, JC (Professor James Vickers)
ID Code:101727
Year Published:2015
Web of Science® Times Cited:5
Deposited By:Wicking Dementia Research and Education Centre
Deposited On:2015-07-02
Last Modified:2017-11-06
Downloads:112 View Download Statistics

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