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The BDNF Val66Met polymorphism moderates the relationship between cognitive reserve and executive function

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posted on 2023-05-18, 11:39 authored by Ward, D, Mathew SummersMathew Summers, Saunders, NLJ, Ritchie, K, Jeffery SummersJeffery Summers, James VickersJames Vickers
The concept of cognitive reserve (CR) has been proposed to account for observed discrepancies between pathology and its clinical manifestation due to underlying differences in brain structure and function. In 433 healthy older adults participating in the Tasmanian Healthy Brain Project, we investigated whether common polymorphic variations in apolipoprotein E (APOE) or brain-derived neurotrophic factor (BDNF) influenced the association between CR contributors and cognitive function in older adults. We show that BDNF Val66Met moderates the association between CR and executive function. CR accounted for 8.5% of the variance in executive function in BDNF Val homozygotes, but CR was a nonsignificant predictor in BDNF Met carriers. APOE polymorphisms were not linked to the influence of CR on cognitive function. This result implicates BDNF in having an important role in capacity for building or accessing CR.

History

Publication title

Translational Psychiatry

Volume

5

Article number

e590

Number

e590

Pagination

1-6

ISSN

2158-3188

Department/School

Wicking Dementia Research Education Centre

Publisher

Nature Publishing Group

Place of publication

United Kingdom

Rights statement

Licensed under a Creative Commons Attribution 4.0 International License http://creativecommons.org/licenses/ by/4.0/

Repository Status

  • Open

Socio-economic Objectives

Clinical health not elsewhere classified

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