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Microglia: dismantling and rebuilding circuits after acute neurological injury

Citation

Ziebell, JM and Adelson, PD and Lifshitz, J, Microglia: dismantling and rebuilding circuits after acute neurological injury, Metabolic Brain Disease, 30, (2) pp. 393-400. ISSN 0885-7490 (2015) [Refereed Article]

Copyright Statement

Copyright 2014 Springer Science+Business Media New York

DOI: doi:10.1007/s11011-014-9539-y

Abstract

The brain is comprised of neurons and its support system including astrocytes, glial cells and microglia, thereby forming neurovascular units. Neurons require support from glial cells to establish and maintain functional circuits, but microglia are often overlooked. Microglia function as the immune cell of the central nervous system, acting to monitor the microenvironment for changes in signaling, pathogens and injury. More recently, other functional roles for microglia within the healthy brain have been identified, including regulating synapse formation, elimination and function. This review aims to highlight and discuss these alternate microglial roles in the healthy and in contrast, diseased brain with a focus on two acute neurological diseases, traumatic brain injury and epilepsy. In these conditions, microglial roles in synaptic stripping and stabilization as part of neuronal:glial interactions may position them as mediators of the transition between injury-induced circuit dismantling and subsequent reorganization. Increased understanding of microglia roles could identify therapeutic targets to mitigate the consequences of neurological disease.

Item Details

Item Type:Refereed Article
Keywords:microglia, synaptic stripping, neurological disease, traumatic brain injury, epilepsy
Research Division:Medical and Health Sciences
Research Group:Neurosciences
Research Field:Neurosciences not elsewhere classified
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Nervous System and Disorders
Author:Ziebell, JM (Dr Jenna Ziebell)
ID Code:101713
Year Published:2015
Web of Science® Times Cited:11
Deposited By:Wicking Dementia Research and Education Centre
Deposited On:2015-07-02
Last Modified:2017-11-06
Downloads:0

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