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Kinin Receptor Antagonists as Potential Neuroprotective Agents in Central Nervous System Injury

Citation

Thornton, E and Ziebell, JM and Leonard, AV and Vink, R, Kinin Receptor Antagonists as Potential Neuroprotective Agents in Central Nervous System Injury, Molecules: A Journal of Synthetic Organic and Natural Product Chemistry, 15 pp. 6598-6618. ISSN 1420-3049 (2010) [Refereed Article]


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Copyright 2010 The Authors Licenced under the Creative Commons Attribution license 3.0 http://creativecommons.org/licenses/by/3.0/

DOI: doi:10.3390/molecules15096598

Abstract

Injury to the central nervous system initiates complex physiological, cellular and molecular processes that can result in neuronal cell death. Of interest to this review is the activation of the kinin family of neuropeptides, in particular bradykinin and substance P. These neuropeptides are known to have a potent pro-inflammatory role and can initiate neurogenic inflammation resulting in vasodilation, plasma extravasation and the subsequent development of edema. As inflammation and edema play an integral role in the progressive secondary injury that causes neurological deficits, this review critically examines kinin receptor antagonists as a potential neuroprotective intervention for acute brain injury, and more specifically, traumatic brain and spinal cord injury and stroke.

Item Details

Item Type:Refereed Article
Keywords:brain injury, neurotrauma, stroke, neuropeptides, kinins
Research Division:Medical and Health Sciences
Research Group:Neurosciences
Research Field:Neurosciences not elsewhere classified
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Nervous System and Disorders
ID Code:101709
Year Published:2010
Web of Science® Times Cited:26
Deposited By:Wicking Dementia Research and Education Centre
Deposited On:2015-07-02
Last Modified:2015-09-28
Downloads:124 View Download Statistics

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