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Kinin Receptor Antagonists as Potential Neuroprotective Agents in Central Nervous System Injury
Citation
Thornton, E and Ziebell, JM and Leonard, AV and Vink, R, Kinin Receptor Antagonists as Potential Neuroprotective Agents in Central Nervous System Injury, Molecules: A Journal of Synthetic Organic and Natural Product Chemistry, 15 pp. 6598-6618. ISSN 1420-3049 (2010) [Refereed Article]
 | PDF (Kinin review) 198Kb |
Copyright Statement
Copyright 2010 The Authors Licenced under the Creative Commons Attribution license 3.0 http://creativecommons.org/licenses/by/3.0/
DOI: doi:10.3390/molecules15096598
Abstract
Injury to the central nervous system initiates complex physiological, cellular and
molecular processes that can result in neuronal cell death. Of interest to this review is the
activation of the kinin family of neuropeptides, in particular bradykinin and substance P.
These neuropeptides are known to have a potent pro-inflammatory role and can initiate
neurogenic inflammation resulting in vasodilation, plasma extravasation and the
subsequent development of edema. As inflammation and edema play an integral role in the
progressive secondary injury that causes neurological deficits, this review critically
examines kinin receptor antagonists as a potential neuroprotective intervention for acute
brain injury, and more specifically, traumatic brain and spinal cord injury and stroke.
Item Details
| Item Type: | Refereed Article |
|---|---|
| Keywords: | brain injury, neurotrauma, stroke, neuropeptides, kinins |
| Research Division: | Biomedical and Clinical Sciences |
| Research Group: | Neurosciences |
| Research Field: | Neurosciences not elsewhere classified |
| Objective Division: | Health |
| Objective Group: | Clinical health |
| Objective Field: | Clinical health not elsewhere classified |
| ID Code: | 101709 |
| Year Published: | 2010 |
| Web of Science® Times Cited: | 34 |
| Deposited By: | Wicking Dementia Research and Education Centre |
| Deposited On: | 2015-07-02 |
| Last Modified: | 2015-09-28 |
| Downloads: | 241 View Download Statistics |
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