Al-Aubaidy, HAM and Hadi, NR and Alzubaidi, FA and Jamil, DA, The protective roles of microgynon and nordiol in controlling the levels of lipid peroxidation: a comparative study on female rats, World Journal of Pharmacy and Pharmaceutical Sciences, 4, (6) pp. 80-89. ISSN 2278-4357 (2015) [Refereed Article]
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Aims: This study aims to evaluate the effects of oral contraception (Microgynon and Nordiol) on the level of lipid peroxidation as a part of oxidative stress progression in female rats. Oral contraception were used.
Materials & Methods: Thirty rats (females) were included in this study. They were divided into 5 groups (six in each group): a control group was maintained on normal standard chow diet, while the other 4 groups received high cholesterol diet for 14 weeks. After 14 weeks, blood samples were taken randomly from 6 rats. The remaining 18 rats were randomly divided into 3 groups (6 rats in each), the first group continued on high cholesterol diet and distilled water for 6 weeks and served as self-control group. The remaining 2 groupscontinued on high cholesterol diet and were given one of the oral contraceptives mentioned above for 6 weeks.
Results: Our data showed that Microgynon treatment resulted in a significant reduction in serum GSH with no significant changes in MDA, CAT and GST activities. However, Nordiol treatment has no significant effects on serum level of GSH, MDA, CAT.
Conclusion: The controversial findings proves the effects of the two types of the oral contraception on lipid peroxidation via different metabolic pathways.
|Item Type:||Refereed Article|
|Keywords:||oral contraceptives, lipid peroxidation, antioxidants|
|Research Division:||Biomedical and Clinical Sciences|
|Research Group:||Medical biochemistry and metabolomics|
|Research Field:||Medical biochemistry - carbohydrates|
|Objective Group:||Clinical health|
|Objective Field:||Clinical health not elsewhere classified|
|UTAS Author:||Al-Aubaidy, HAM (Dr Hayder Al-Aubaidy)|
|UTAS Author:||Jamil, DA (Dr Dina Jamil)|
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