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Strain-induced 'band flips' in cyclodecaamylose and higher homologues
journal contribution
posted on 2023-05-18, 11:27 authored by Jacob, J, Gessler, K, Hoffmann, D, Sanbe, H, Koizumi, K, Steven SmithSteven Smith, Takaha, T, Saenger, WIn the well–known cyclodextrins, all glucose units are cis-oriented and connected by O3···O2´ hydrogen bonds forming cyclically closed bands. In larger cyclodextrins (cycloamyloses) with 10 and more glucoses, strain induced in the macrocycle is relieved by two 180º flips to trans orientation between diametrically opposed glucose units. These two “band flips“ are stabilized by hydrogen bonds (O3···O5´ and O3···O6´), and lead to butterflylike structures. In the figures, cyclodextrins with 7 and 14 glucoses are shown; atoms O2, O3 are red, O6 blue, C6 grey, arrows mark chain direction, and dashed lines indicate hydrogen bonds.
History
Publication title
Angewandte Chemie International EditionVolume
37Issue
5Pagination
606-609ISSN
1433-7851Department/School
School of Natural SciencesPublisher
Wiley-V C H Verlag GmbhPlace of publication
Po Box 10 11 61, Weinheim, Germany, D-69451Rights statement
Copyright 1998 WILEY-VCH Verlag GmbHRepository Status
- Restricted