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18F-fluorodeoxyglucose versus 18F-fluoromethylcholine positron emission tomography in the detection of ductal carcinoma in situ of the breast

Citation

Butler-Henderson, K and Lenzo, NP and Loh, NK and Price, RI and Lee, AH, 18F-fluorodeoxyglucose versus 18F-fluoromethylcholine positron emission tomography in the detection of ductal carcinoma in situ of the breast, Jacobs Journal of Cancer Science and Research, 1, (2) pp. 9-13. ISSN 2380-114X (2015) [Refereed Article]


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Copyright 2015 Kerryn Licensed under Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0) https://creativecommons.org/licenses/by-nc/4.0/

Official URL: http://cancerscienceandresearch.jacobspublishers.c...

Abstract

Purpose: Poor sensitivity and accuracy have been reported using 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET) in the detection of ductal carcinoma in situ (DCIS), yet no reference to the use of 18F-fluoromethylcholine (FCH) PET can be identified in the in situ breast cancer literature. This study determined the tumour to background ratio for cases where both FDG and FCH-PET were used to detect DCIS.

Methods: Patients with newly diagnosed DCIS were recruited from the Breast Assessment Centre at a Western Australian teaching hospital. During the 16 month recruitment period, two patients consented to participate in the study. Each underwent a FDG-PET and a FCH-PET scan. The activity within the tumour was measured against the activity in the contralateral breast to obtain the tumour-to-background ratio.

Results: The DCIS lesions were visualised on the FDG and FCH-PET scans in both patients. The tumour to background ratios were 1.49:1 and 1.47:1 for the FDG-PET scan, compared to 1.49:1 and 1.20:1 for the FCH-PET scan. Both patients had comedo/ solid unifocal DCIS, with intermediate and high nuclear grade.

Conclusions: FDG-PET gave a higher tumour to background ratio than FCH-PET in the detection of DCIS and hence appeared to be the preferred radiopharmaceutical for imaging and hand-held PET technology in in situ breast cancer management.

Item Details

Item Type:Refereed Article
Keywords:18F-fluorodeoxyglucose, 18F-fluoromethylcholine, positron emission tomograph, ductal carcinoma in situ, breast cancer
Research Division:Medical and Health Sciences
Research Group:Oncology and Carcinogenesis
Research Field:Oncology and Carcinogenesis not elsewhere classified
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Cancer and Related Disorders
Author:Butler-Henderson, K (Dr Kerryn Butler-Henderson)
ID Code:101565
Year Published:2015
Deposited By:Tasmanian School of Business and Economics
Deposited On:2015-06-26
Last Modified:2016-08-15
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