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18F-fluorodeoxyglucose versus 18F-fluoromethylcholine positron emission tomography in the detection of ductal carcinoma in situ of the breast
Butler-Henderson, K and Lenzo, NP and Loh, NK and Price, RI and Lee, AH, 18F-fluorodeoxyglucose versus 18F-fluoromethylcholine positron emission tomography in the detection of ductal carcinoma in situ of the breast, Jacobs Journal of Cancer Science and Research, 1, (2) pp. 9-13. ISSN 2380-114X (2015) [Refereed Article]
Copyright 2015 Kerryn Licensed under Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0) https://creativecommons.org/licenses/by-nc/4.0/
Official URL: http://cancerscienceandresearch.jacobspublishers.c...
Purpose: Poor sensitivity and accuracy have been reported using 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET) in the detection of ductal carcinoma in situ (DCIS), yet no reference to the use of 18F-fluoromethylcholine (FCH) PET can be identified in the in situ breast cancer literature. This study determined the tumour to background ratio for cases where both FDG and FCH-PET were used to detect DCIS.
Methods: Patients with newly diagnosed DCIS were recruited from the Breast Assessment Centre at a Western Australian teaching hospital. During the 16 month recruitment period, two patients consented to participate in the study. Each underwent a FDG-PET and a FCH-PET scan. The activity within the tumour was measured against the activity in the contralateral breast to obtain the tumour-to-background ratio.
Results: The DCIS lesions were visualised on the FDG and FCH-PET scans in both patients. The tumour to background ratios were 1.49:1 and 1.47:1 for the FDG-PET scan, compared to 1.49:1 and 1.20:1 for the FCH-PET scan. Both patients had comedo/ solid unifocal DCIS, with intermediate and high nuclear grade.
Conclusions: FDG-PET gave a higher tumour to background ratio than FCH-PET in the detection of DCIS and hence appeared to be the preferred radiopharmaceutical for imaging and hand-held PET technology in in situ breast cancer management.
|Item Type:||Refereed Article|
|Keywords:||18F-fluorodeoxyglucose, 18F-fluoromethylcholine, positron emission tomograph, ductal carcinoma in situ, breast cancer|
|Research Division:||Biomedical and Clinical Sciences|
|Research Group:||Oncology and carcinogenesis|
|Research Field:||Oncology and carcinogenesis not elsewhere classified|
|Objective Group:||Clinical health|
|Objective Field:||Clinical health not elsewhere classified|
|UTAS Author:||Butler-Henderson, K (Associate Professor Kerryn Butler-Henderson)|
|Downloads:||89 View Download Statistics|
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