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A central role for the peroxisomal membrane in glyoxylate cycle function


Kunze, M and Pracharoenwattana, I and Smith, SM and Hartig, A, A central role for the peroxisomal membrane in glyoxylate cycle function, Biochimica et Biophysica Acta: Molecular Cell Research, 1763, (12) pp. 1441-1452. ISSN 0167-4889 (2006) [Refereed Article]

Copyright Statement

Copyright 2006 Elsevier B.V.

DOI: doi:10.1016/j.bbamcr.2006.09.009


The glyoxylate cycle provides the means to convert C2-units to C4-precursors for biosynthesis, allowing growth on fatty acids and C2-compounds. The conventional view that the glyoxylate cycle is contained within peroxisomes in fungi and plants is no longer valid. Glyoxylate cycle enzymes are located both inside and outside the peroxisome. Thus, the operation of the glyoxylate cycle requires transport of several intermediates across the peroxisomal membrane. Glyoxylate cycle progression is also dependent upon mitochondrial metabolism. An understanding of the operation and regulation of the glyoxylate cycle, and its integration with cellular metabolism, will require further investigation of the participating metabolite transporters in the peroxisomal membrane.

Item Details

Item Type:Refereed Article
Keywords:glyoxylate cycle, peroxisomes, membrane transport, metabolic compartmentation, saccharomyces cerevisiae, Arabidopsis thaliana
Research Division:Biological Sciences
Research Group:Plant biology
Research Field:Plant physiology
Objective Division:Expanding Knowledge
Objective Group:Expanding knowledge
Objective Field:Expanding knowledge in the biological sciences
UTAS Author:Smith, SM (Professor Steven Smith)
ID Code:101511
Year Published:2006
Web of Science® Times Cited:136
Deposited By:Plant Science
Deposited On:2015-06-25
Last Modified:2015-09-24

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