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Karrikins force a rethink of strigolactone mode of action

Citation

Waters, MT and Scaffidi, A and Flematti, GR and Smith, SM, Karrikins force a rethink of strigolactone mode of action, Plant Signaling and Behavior, 7, (8) pp. 969-972. ISSN 1559-2324 (2012) [Refereed Article]

Copyright Statement

Copyright 2012 Landes Bioscience

DOI: doi:10.4161/psb.20977

Abstract

Strigolactones (SL) and karrikins (KAR) both contain essential butenolide moieties, and both require the F-box protein MAX2 to control seed germination and photomorphogenesis in Arabidopsis thaliana. A new discovery that SL and KAR also require related α/β-hydrolase proteins for such activity suggests that they operate through a similar molecular mechanism. Based on structural similarity, a previously proposed mode of action for SL was also considered for KAR, but recent structure-activity studies suggest that this mechanism may not apply. Here we rationalise these observations into a hypothesis whereby different α/β-hydrolases distinguish SL and KAR by virtue of their non-butenolide moieties and catalyze nucleophilic attack on the butenolide. The products would be different for SL and KAR, and in the case of SL they have no biological activity. The inference is that nucleophilic attack on SL and KAR by α/β-hydrolases is required for their bioactivity, but the hydrolysis products are not.

Item Details

Item Type:Refereed Article
Keywords:signalling, strigolactone, karrikin, seed germination, Arabidopsis thaliana, butenolide, α/β-hydrolase, MAX2, KAI2, D14
Research Division:Biological Sciences
Research Group:Plant Biology
Research Field:Plant Physiology
Objective Division:Expanding Knowledge
Objective Group:Expanding Knowledge
Objective Field:Expanding Knowledge in the Biological Sciences
Author:Smith, SM (Professor Steven Smith)
ID Code:101452
Year Published:2012
Deposited By:Plant Science
Deposited On:2015-06-24
Last Modified:2017-11-02
Downloads:0

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