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Common sequence variation in the VEGFC gene is associated with diabetic retinopathy and diabetic macular edema

Citation

Kaidonis, G and Burdon, KP and Gillies, MC and Abhary, S and Essex, RW and Chang, JH and Pal, B and Pefkianaki, M and Daniell, M and Lake, S and Petrovsky, N and Hewitt, AW and Jenkins, A and Lamoureux, EL and Gleadle, JM and Craig, JE, Common sequence variation in the VEGFC gene is associated with diabetic retinopathy and diabetic macular edema, Ophthalmology, 122, (9) pp. 1828-1836. ISSN 0161-6420 (2015) [Refereed Article]

Copyright Statement

Copyright 2015 by the American Academy of Ophthalmology

DOI: doi:10.1016/j.ophtha.2015.05.004

Abstract

Purpose: To investigate associations between single nucleotide polymorphisms (SNPs) in the VEGFC gene and the development of diabetic retinopathy (DR) in white patients with type 1 diabetes mellitus (T1DM) or type 2 diabetes mellitus (T2DM).

Design: Cross-sectional, case control study.

Participants: White patients with T1DM or T2DM (n = 2899) were recruited from ophthalmology and endocrine clinics in Australia and the United Kingdom. Patients with T2DM were required to have diabetes mellitus (DM) for at least 5 years and be receiving oral hypoglycemic treatment or insulin.

Methods: Participants with DM but "no DR" (n = 980) were compared with 1919 participants with DM and "any DR." Three VEGFC SNPs were associated with DR after logistic regression: rs17697419 (P=0.001; OR, 0.67; confidence interval [CI], 0.520.85), rs17697515 (P=.001; OR, 0.62; CI, 0.470.81), and rs2333526 (P=0.005; OR, 0.69; CI, 0.540.90). rs17697515 Was also specifically associated with DME in those with T2DM (P=0.004; OR, 0.53; CI, 0.350.82). Haplotype analysis revealed 2 significantly associated haplotypes, both protective against DR development.

Main Outcome Measures: Odds ratios (ORs) were determined for associations with DR of VEGFC tag SNPs, individually and within haplotypes. Logistic regression was used to adjust for clinical covariates, including DM type, age, sex, DM duration, hypertension, nephropathy, HbA1c, and smoking./p>

Results: Participants with DM but "no DR" (n=980) were compared with 1919 participants with DM and "any DR." Three VEGFC SNPs were associated with DR after logistic regression: rs17697419 (P=0.001; OR, 0.67; confidence interval [CI], 0.52-0.85), rs17697515 (P=0.001; OR, 0.62; CI, 0.47-0.81), and rs2333526 (P=0.005; OR, 0.69; CI, 0.54-0.90). rs17697515 Was also specifically associated with DME in those with T2DM (P=0.004; OR, 0.53; CI, 0.35-0.82). Haplotype analysis revealed 2 significantly associated haplotypes, both protective against DR development.

Conclusions: Significant associations were found between VEGFC tag SNPs (individually and within haplotypes) and the presence of any DR or DME in white participants with T1DM and T2DM.

Item Details

Item Type:Refereed Article
Keywords:diabetic retinopathy, genetics
Research Division:Medical and Health Sciences
Research Group:Ophthalmology and Optometry
Research Field:Ophthalmology
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Hearing, Vision, Speech and Their Disorders
Author:Burdon, KP (Associate Professor Kathryn Burdon)
Author:Hewitt, AW (Professor Alex Hewitt)
ID Code:101367
Year Published:2015
Web of Science® Times Cited:6
Deposited By:Menzies Institute for Medical Research
Deposited On:2015-06-19
Last Modified:2017-11-07
Downloads:0

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