Kao, KT and Abidi, N and Ranasinha, S and Brown, J and Rodda, C and McCallum, Z and Zacharin, M and Simm, PJ and Magnussen, CG and Sabin, MA, Low vitamin D is associated with hypertension in paediatric obesity, Journal of Paediatrics and Child Health, 51, (12) pp. 1207-1213. ISSN 1034-4810 (2015) [Refereed Article]
Copyright 2015 The Authors
Aim: The aim of this paper was to investigate the relationship between circulating 25-hydroxyvitamin D (25(OH)D) and cardio-metabolic risk factors in a large cohort of obese youth attending tertiary paediatric obesity services.
Methods: We conducted a retrospective cross-sectional study. Data were retrospectively collected from all new consultations of children and adolescents attending obesity outpatient clinics between 2008 and 2011 at the two major paediatric hospitals in Melbourne, Australia. Information collected included demographics, anthropometry, blood pressure, pubertal staging, body composition and fasting serum levels of 25(OH)D, glucose, insulin, cholesterol, triglyceride, high-density lipoprotein, liver function, calcium and phosphate.
Results: 25(OH)D data were available in 229 patients (age 3–18 years; 116 men; mean (standard deviation) body mass index (BMI) Z-score 2.5 (0.5) ). One hundred four (45%) participants were 25(OH)D deficient (<50 nmol/L). Lower serum 25(OH)D levels were associated with higher BMI Z-score (P-trend = 0.001), total fat mass (P-trend = 0.009), systolic (P-trend = 0.03) and diastolic blood pressures(P-trend = 0.009). In multivariable-adjusted regression analysis, 25(OH)D was significantly lower in those with elevated blood pressure after adjustment for BMI (P-trend = 0.004) or total fat mass (P-trend = 0.01).
Conclusion: Overweight and obese youth attending specialist obesity services have a high prevalence of vitamin D deficiency. In this population, lower levels of vitamin D were seen in those with greater adiposity, and independent of this, in those who had higher blood pressure.
|Item Type:||Refereed Article|
|Keywords:||children, hypertension, metabolic syndrome, obesity, vitamin D|
|Research Division:||Health Sciences|
|Research Field:||Epidemiology not elsewhere classified|
|Objective Group:||Clinical health|
|Objective Field:||Clinical health not elsewhere classified|
|UTAS Author:||Magnussen, CG (Associate Professor Costan Magnussen)|
|Web of Science® Times Cited:||22|
|Deposited By:||Menzies Institute for Medical Research|
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