File(s) under permanent embargo
Chromatin remodeler mutations in human cancers: epigenetic implications
journal contribution
posted on 2023-05-22, 23:45 authored by Skulte, KA, Phan, L, Clark, SJ, Phillippa TaberlayPhillippa TaberlayChromatin remodeler complexes exhibit the ability to alter nucleosome composition and positions, with seemingly divergent roles in the regulation of chromatin architecture and gene expression. The outcome is directed by subunit variation and interactions with accessory factors. Recent studies have revealed that subunits of chromatin remodelers display an unexpectedly high mutation rate and/or are inactivated in a number of cancers. Consequently, a repertoire of epigenetic processes are likely to be affected, including interactions with histone modifying factors, as well as the ability to precisely modulate nucleosome positions, DNA methylation patterns and potentially, higher-order genome structure. However, the true significance of chromatin remodeler genetic aberrations in promoting a cascade of epigenetic changes, particularly during initiation and progression of cancer, remains largely unknown.
History
Publication title
EpigenomicsVolume
6Issue
4Pagination
397-414ISSN
1750-1911Department/School
Tasmanian School of MedicinePublisher
Future MedicinePlace of publication
United KingdomRepository Status
- Restricted