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Nutrition, Genes and Modern Disease: A Current Dilemma or a Legacy of our Past


Myers, S and Williamson, S, Nutrition, Genes and Modern Disease: A Current Dilemma or a Legacy of our Past, Journal of Diabetes & Metabolism, 5, (7) pp. 1-5. ISSN 2155-6156 (2014) [Refereed Article]


Copyright Statement

Copyright 2014 Myers S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

DOI: doi:10.4172/2155-6156.1000393


Contemporary humans are genetically adapted to the environment that their ancestors survived in and that consequently selected their genetic makeup. Since the agricultural revolution some 10,000 years ago, the lifestyles and dietary requirements of modern humans have changed dramatically. It is suggested that these changes have occurred too recently on an evolutionary time scale for the modern human genome to adapt. Therefore, our ancestral genome is ill-suited for our current modern consumption and existence, and thus contributes to diseases associated with contemporary lifestyles, such as cardiovascular disease, obesity and type 2 diabetes. It is therefore suggested that a diet similar to our ancestors could circumvent many of our modern illnesses and serve as a reference for better nutrition, health, and longevity. Although this model should certainly be commended for its simplistic dietary practices that no doubt improve health and well-being; its premise is cemented in the thrifty genome hypothesis and the fact that humans are modern hunters and gatherers whose genome is ill-suited for modern diets. This is a disjointed view of modern humans and our ability to evolve under different eco regions and nutritional pressures through post-genomic and post-transcriptional changes in our genome. Accordingly, a major challenge associated with nutritional research is to understand how these changes in our genome reflect on our nutrition habits and lifestyles to ameliorate many of our modern lifestyle diseases.

Item Details

Item Type:Refereed Article
Keywords:Diet and genetics, Paleolithic, Hunters and gatherers, Type 2 diabetes, Thrifty genome, Epigenetics
Research Division:Biomedical and Clinical Sciences
Research Group:Nutrition and dietetics
Research Field:Nutrigenomics and personalised nutrition
Objective Division:Expanding Knowledge
Objective Group:Expanding knowledge
Objective Field:Expanding knowledge in the biological sciences
UTAS Author:Myers, S (Dr Stephen Myers)
ID Code:101170
Year Published:2014
Deposited By:Health Sciences B
Deposited On:2015-06-11
Last Modified:2015-09-16
Downloads:243 View Download Statistics

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