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Caveolin-1 is necessary for hepatic oxidative lipid metabolism: evidence for crosstalk between caveolin-1 and bile acid signaling

Citation

Fernandez-Rojo, MA and Gongora, M and Fitzsimmons, RL and Martel, N and Martin, SD and Nixon, SJ and Brooks, AJ and Ikonomopoulou, MP and Martin, S and Lo, HP and Myers, SA and Restall, C and Ferguson, C and Pilch, PF and McGee, SL and Anderson, RL and Waters, MJ and Hancock, JF and Grimmond, SM and Muscat, GEO and Parton, RG, Caveolin-1 is necessary for hepatic oxidative lipid metabolism: evidence for crosstalk between caveolin-1 and bile acid signaling, Cell Reports, 4, (2) pp. 238-247. ISSN 2211-1247 (2013) [Refereed Article]


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Copyright 2013 The Authors Licenced under Attribution-NonCommercial-NoDerivs 3.0 Unported (CC BY-NC-ND 3.0) http://creativecommons.org/licenses/by-nc-nd/3.0/

DOI: doi:10.1016/j.celrep.2013.06.017

Abstract

Caveolae and caveolin-1 (CAV1) have been linked to several cellular functions. However, a model explaining their roles in mammalian tissues in vivo is lacking. Unbiased expression profiling in several tissues and cell types identified lipid metabolism as the main target affected by CAV1 deficiency. CAV1-/- mice exhibited impaired hepatic peroxisome proliferator-activated receptor α (PPARα)-dependent oxidative fatty acid metabolism and ketogenesis. Similar results were recapitulated in CAV1-deficient AML12 hepatocytes, suggesting at least a partial cell-autonomous role of hepatocyte CAV1 in metabolic adaptation to fasting. Finally, our experiments suggest that the hepatic phenotypes observed in CAV1-/- mice involve impaired PPARα ligand signaling and attenuated bile acid and FXRα signaling. These results demonstrate the significance of CAV1 in (1) hepatic lipid homeostasis and (2) nuclear hormone receptor (PPARα, FXRα, and SHP) and bile acid signaling.

Item Details

Item Type:Refereed Article
Keywords:Lipid metabolism
Research Division:Biological Sciences
Research Group:Biochemistry and Cell Biology
Research Field:Cell Metabolism
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Diabetes
Author:Myers, SA (Dr Stephen Myers)
ID Code:101164
Year Published:2013
Web of Science® Times Cited:18
Deposited By:Health Sciences B
Deposited On:2015-06-11
Last Modified:2017-11-02
Downloads:147 View Download Statistics

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