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The Canadian Healthy Infant Longitudinal Development (CHILD) birth cohort study: assessment of environmental exposures

Citation

Takaro, TK and Scott, JA and Allen, RW and Anand, SS and Becker, AB and Befus, AD and Brauer, M and Duncan, J and Lefebvre, DL and Lou, W and Mandhane, PJ and McLean, KE and Miller, G and Sbihi, H and Shu, H and Subbarao, P and Turvey, SE and Wheeler, AJ and Zeng, L and Sears, MR and Brook, JR, and the CHILD study investigators, The Canadian Healthy Infant Longitudinal Development (CHILD) birth cohort study: assessment of environmental exposures, Journal of Exposure Science and Environmental Epidemiology, 25 pp. 580-592. ISSN 1559-0631 (2015) [Refereed Article]


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Copyright 2015 Nature America, Inc. Licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License http://creativecommons.org/licenses/by-nc-nd/4.0/

DOI: doi:10.1038/jes.2015.7

Abstract

The Canadian Healthy Infant Longitudinal Development birth cohort was designed to elucidate interactions between environment and genetics underlying development of asthma and allergy. Over 3600 pregnant mothers were recruited from the general population in four provinces with diverse environments. The child is followed to age 5 years, with prospective characterization of diverse exposures during this critical period. Key exposure domains include indoor and outdoor air pollutants, inhalation, ingestion and dermal uptake of chemicals, mold, dampness, biological allergens, pets and pests, housing structure, and living behavior, together with infections, nutrition, psychosocial environment, and medications. Assessments of early life exposures are focused on those linked to inflammatory responses driven by the acquired and innate immune systems. Mothers complete extensive environmental questionnaires including time-activity behavior at recruitment and when the child is 3, 6, 12, 24, 30, 36, 48, and 60 months old. House dust collected during a thorough home assessment at 3-4 months, and biological specimens obtained for multiple exposure-related measurements, are archived for analyses. Geo-locations of homes and daycares and land-use regression for estimating traffic-related air pollution complement time-activity-behavior data to provide comprehensive individual exposure profiles. Several analytical frameworks are proposed to address the many interacting exposure variables and potential issues of co-linearity in this complex data set.

Item Details

Item Type:Refereed Article
Keywords:biomarkers, infants, exposure, settled dust
Research Division:Medical and Health Sciences
Research Group:Public Health and Health Services
Research Field:Environmental and Occupational Health and Safety
Objective Division:Health
Objective Group:Public Health (excl. Specific Population Health)
Objective Field:Environmental Health
Author:Wheeler, AJ (Dr Amanda Wheeler)
ID Code:101145
Year Published:2015
Web of Science® Times Cited:10
Deposited By:Menzies Institute for Medical Research
Deposited On:2015-06-10
Last Modified:2017-11-04
Downloads:210 View Download Statistics

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