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The Inflammatory Bowel Diseases and Ambient Air Pollution: A Novel Association


Kaplan, GG and Hubbard, J and Korzenik, J and Sands, BE and Panaccione, R and Ghosh, S and Wheeler, AJ and Villeneuve, PJ, The Inflammatory Bowel Diseases and Ambient Air Pollution: A Novel Association, American Journal of Gastroenterology pp. 1-8. ISSN 0002-9270 (2010) [Refereed Article]


Copyright Statement

Copyright 2010 The American College of Gastroenterology Licensed under the Creative Commons Attribution-NonCommercial-No Derivative Works 3.0 Unported License

DOI: doi:10.1038/ajg.2010.252


OBJECTIVES: The inflammatory bowel diseases (IBDs) emerged after industrialization. We studied whether ambient air pollution levels were associated with the incidence of IBD.

METHODS: The health improvement network (THIN) database in the United Kingdom was used to identify incident cases of Crohn's disease (n=367) or ulcerative colitis (n=591), and age- and sex-matched controls. Conditional logistic regression analyses assessed whether IBD patients were more likely to live in areas of higher ambient concentrations of nitrogen dioxide (NO(2)), sulfur dioxide (SO(2)), and particulate matter <10 μm (PM(10)), as determined by using quintiles of concentrations, after adjusting for smoking, socioeconomic status, non-steroidal anti-inflammatory drugs (NSAIDs), and appendectomy. Stratified analyses investigated effects by age.

RESULTS: Overall, NO(2), SO(2), and PM(10) were not associated with the risk of IBD. However, individuals ≤23 years were more likely to be diagnosed with Crohn's disease if they lived in regions with NO(2) concentrations within the upper three quintiles (odds ratio (OR)=2.31; 95% confidence interval (CI)=1.25-4.28), after adjusting for confounders. Among these Crohn's disease patients, the adjusted OR increased linearly across quintile levels for NO(2) (P=0.02). Crohn's disease patients aged 44-57 years were less likely to live in regions of higher NO(2) (OR=0.56; 95% CI=0.33-0.95) and PM(10) (OR=0.48; 95% CI=0.29-0.80). Ulcerative colitis patients ≤25 years (OR=2.00; 95% CI=1.08-3.72) were more likely to live in regions of higher SO(2); however, a dose-response effect was not observed.

CONCLUSIONS: On the whole, air pollution exposure was not associated with the incidence of IBD. However, residential exposures to SO(2) and NO(2) may increase the risk of early-onset ulcerative colitis and Crohn's disease, respectively. Future studies are needed to explore the age-specific effects of air pollution exposure on IBD risk.

Item Details

Item Type:Refereed Article
Keywords:air quality, health, appendicitis
Research Division:Commerce, Management, Tourism and Services
Research Group:Human resources and industrial relations
Research Field:Occupational and workplace health and safety
Objective Division:Health
Objective Group:Public health (excl. specific population health)
Objective Field:Public health (excl. specific population health) not elsewhere classified
UTAS Author:Wheeler, AJ (Dr Amanda Wheeler)
ID Code:101107
Year Published:2010
Web of Science® Times Cited:153
Deposited By:Menzies Institute for Medical Research
Deposited On:2015-06-10
Last Modified:2015-09-17
Downloads:336 View Download Statistics

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