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Office immunotherapy in chronic inflammatory demyelinating polyneuropathy and multifocal motor neuropathy


Dyck, PJ and Taylor, BV and Davies, JL and Mauermann, ML and Litchy, WJ and Klein, CJ and Dyck, PJB, Office immunotherapy in chronic inflammatory demyelinating polyneuropathy and multifocal motor neuropathy, Muscle and Nerve, 52, (4) pp. 488-497. ISSN 0148-639X (2015) [Refereed Article]

Copyright Statement

Copyright 2015 Wiley Periodicals, Inc.

DOI: doi:10.1002/mus.24707


Intravenous immunoglobulin [IVIg], plasma exchange [PE], and corticosteroids are efficacious treatment in chronic inflammatory demyelinating polyneuropathy [CIDP]. IVIg is effective in multifocal motor neuropathy [MMN]. NIS, NIS-weakness, sum scores of raw amplitudes of motor fiber (CMAPs) amplitudes, and Dyck/Rankin score provided reliable measures to detect and scale abnormality and reflect change; they are therefore ideal for office management of response-based immunotherapy (R-IRx) of CIDP. Using efficacious R-IRx, a large early and late therapeutic response (≥ one-fourth were in remission or had recovered) was demonstrated in CIDP. In MMN only an early improvement with late non-significant worsening was observed. The difference in immunotherapy response supports a fundamental difference between CIDP (immune attack on Schwann cells and myelin) and MMN (attack on nodes of Ranvier and axons).

Item Details

Item Type:Refereed Article
Keywords:CIDP, MMN, immune therapy, neurophysiologic tests, signs
Research Division:Medical and Health Sciences
Research Group:Neurosciences
Research Field:Central Nervous System
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Nervous System and Disorders
UTAS Author:Taylor, BV (Professor Bruce Taylor)
ID Code:101096
Year Published:2015
Web of Science® Times Cited:7
Deposited By:Menzies Institute for Medical Research
Deposited On:2015-06-10
Last Modified:2017-11-06

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