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Office immunotherapy in chronic inflammatory demyelinating polyneuropathy and multifocal motor neuropathy
Citation
Dyck, PJ and Taylor, BV and Davies, JL and Mauermann, ML and Litchy, WJ and Klein, CJ and Dyck, PJB, Office immunotherapy in chronic inflammatory demyelinating polyneuropathy and multifocal motor neuropathy, Muscle and Nerve, 52, (4) pp. 488-497. ISSN 0148-639X (2015) [Refereed Article]
Copyright Statement
Copyright 2015 Wiley Periodicals, Inc.
Abstract
Intravenous immunoglobulin [IVIg], plasma exchange [PE], and corticosteroids are efficacious treatment in chronic inflammatory demyelinating polyneuropathy [CIDP]. IVIg is effective in multifocal motor neuropathy [MMN]. NIS, NIS-weakness, sum scores of raw amplitudes of motor fiber (CMAPs) amplitudes, and Dyck/Rankin score provided reliable measures to detect and scale abnormality and reflect change; they are therefore ideal for office management of response-based immunotherapy (R-IRx) of CIDP. Using efficacious R-IRx, a large early and late therapeutic response (≥ one-fourth were in remission or had recovered) was demonstrated in CIDP. In MMN only an early improvement with late non-significant worsening was observed. The difference in immunotherapy response supports a fundamental difference between CIDP (immune attack on Schwann cells and myelin) and MMN (attack on nodes of Ranvier and axons).
Item Details
Item Type: | Refereed Article |
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Keywords: | CIDP, MMN, immune therapy, neurophysiologic tests, signs |
Research Division: | Biomedical and Clinical Sciences |
Research Group: | Neurosciences |
Research Field: | Central nervous system |
Objective Division: | Health |
Objective Group: | Clinical health |
Objective Field: | Clinical health not elsewhere classified |
UTAS Author: | Taylor, BV (Professor Bruce Taylor) |
ID Code: | 101096 |
Year Published: | 2015 |
Web of Science® Times Cited: | 15 |
Deposited By: | Menzies Institute for Medical Research |
Deposited On: | 2015-06-10 |
Last Modified: | 2017-11-06 |
Downloads: | 0 |
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