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Childhood physical performance measures predict adulthood knee cartilage volume and bone area: A 25-year cohort study


Antony, B and Jones, G and Venn, A and Cicuttini, F and March, L and Blizzard, L and Dwyer, T and Cross, M and Ding, C, Childhood physical performance measures predict adulthood knee cartilage volume and bone area: A 25-year cohort study, Arthritis Care & Research, 67, (9) pp. 1263-1271. ISSN 2151-464X (2015) [Refereed Article]

Copyright Statement

2015, American College of Rheumatology

DOI: doi:10.1002/acr.22588


Objective: We aimed to determine the associations between childhood physical performance measures and tibial cartilage volume and tibial bone area in adults 25 years later.

Methods: Participants (n=330, ages 3141 years, female 47%) were selected from the Australian Schools Health and Fitness Survey of 1985. The participants underwent T1-weighted fat-suppressed magnetic resonance imaging (MRI) of their knees. Tibial bone area and cartilage volume were measured from MRI. Childhood measures, including physical work capacity at 170 beats per minute (PWC170), leg strength, number of sit-ups, long-run, and short-run were measured in 1985. PWC170 and leg strength measures were repeated after 20 years in their adulthood. Linear regression analysis was used to determine the association of performance measures with cartilage volume.

Results: There were consistent positive associations of all childhood measures, including PWC170 (β=0.38 cm2 per 10 watts, 95% confidence interval [95% CI] 0.15, 0.60), leg strength, long-run, short-run, and sit-ups with adult medial and total tibial bone area. Similarly, there was an association of PWC170 and sit-ups with adult medial tibial cartilage volume. After further adjustment for tibial bone area, the association between PWC170 and medial and total (β=0.08 cm3 per 10 watts, 95% CI 0.02, 0.10) tibial cartilage volume decreased in magnitude but remained significant.

Conclusion: Childhood physical performance measures, especially PWC170, were associated with knee tibial bone area and cartilage volume in adulthood. The associations with cartilage volume appeared to be partially mediated by bone area. This suggests physical performance measures in childhood can independently influence adult knee structures.

Item Details

Item Type:Refereed Article
Keywords:adulthood, bone, cartilage, childhood fitness, knee
Research Division:Health Sciences
Research Group:Epidemiology
Research Field:Epidemiology not elsewhere classified
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Antony, B (Dr Benny Eathakkattu Antony)
UTAS Author:Jones, G (Professor Graeme Jones)
UTAS Author:Venn, A (Professor Alison Venn)
UTAS Author:Blizzard, L (Professor Leigh Blizzard)
UTAS Author:Ding, C (Professor Chang-Hai Ding)
ID Code:101089
Year Published:2015
Web of Science® Times Cited:7
Deposited By:Menzies Institute for Medical Research
Deposited On:2015-06-10
Last Modified:2017-11-03

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