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Genetic determinants of epigenetic patterns: providing insight into disease

Citation

Cazaly, E and Charlesworth, J and Dickinson, JL and Holloway, AF, Genetic determinants of epigenetic patterns: providing insight into disease, Molecular Medicine, 21 pp. 400-409. ISSN 1076-1551 (2015) [Refereed Article]

Copyright Statement

Copyright 2015 The Authors

DOI: doi:10.2119/molmed.2015.00001

Abstract

The field of epigenetics and our understanding of the mechanisms which regulate the establishment, maintenance and heritability of epigenetic patterns continue to grow at a remarkable rate. This is providing increased understanding of the role of epigenetic changes in disease, insight into the underlying causes of these epigenetic changes and revealing new avenues for therapeutic intervention. Epigenetic modifiers are increasingly being pursued as therapeutic targets in a range of diseases, with a number of agents targeting epigenetic modifications already proving effective in diseases such as cancer. While it is well established that DNA mutations and aberrant expression of epigenetic modifiers play a key role in disease, attention is now turning to the interplay between genetic and epigenetic factors in complex disease aetiology. The role of genetic variability in determining epigenetic profiles, which can then be modified by environmental and stochastic factors, is becoming more apparent. Understanding the interplay between genetic and epigenetic factors is likely to aid in identifying individuals most likely to benefit from epigenetic therapies. This goal is coming closer to realization due to continual advances in laboratory and statistical tools enabling improvements in the integration of genomic, epigenomic and phenotypic data.

Item Details

Item Type:Refereed Article
Keywords:epigenomic, genome, sequence variation, epimutation, disease
Research Division:Biological Sciences
Research Group:Genetics
Research Field:Epigenetics (incl. Genome Methylation and Epigenomics)
Objective Division:Expanding Knowledge
Objective Group:Expanding Knowledge
Objective Field:Expanding Knowledge in the Biological Sciences
Author:Cazaly, E (Ms Emma Cazaly)
Author:Charlesworth, J (Dr Jac Charlesworth)
Author:Dickinson, JL (Associate Professor Joanne Dickinson)
Author:Holloway, AF (Associate Professor Adele Holloway)
ID Code:101086
Year Published:2015
Web of Science® Times Cited:1
Deposited By:Menzies Institute for Medical Research
Deposited On:2015-06-10
Last Modified:2017-11-07
Downloads:0

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