Wluka, AE and Ding, C and Wang, Y and Jones, G and Urquhart, DM and Cicuttini, FM, Aspirin is associated with reduced cartilage loss in knee osteoarthritis: Data from a cohort study, Maturitas, 81, (3) pp. 394-397. ISSN 0378-5122 (2015) [Refereed Article]
Copyright 2015 Elsevier Ireland Ltd.
Official URL: http://dx.doi.org/10.1016/j.maturitas.2015.04.015
Objectives: Aspirin, widely used in the prevention of cardiovascular disease, in low dose, has anti-inflammatory and vasculoprotective effects: both of these processes contribute to the pathogenesis of osteoarthritis. We examined whether use of low dose aspirin affects change in knee cartilage volume in osteoarthritis.
Methods: Participants from the Melbourne osteoarthritis cohort were classified as users and non-users of aspirin, according to baseline use (≤300mg/day). Their knees were imaged twice over 2 years. Tibial cartilage volumes were measured and change calculated.
Results: Twenty one (18%) of 117 eligible participants were aspirin users. Annual change in medial tibial cartilage volume was -43mm3 (95% confidence intervals (CI) -93, 10) in aspirin users and -101mm3 (95% CI -125, -77) in non-users (p = 0.043 for difference) after adjusting for age, gender, BMI and radiographic severity. Similar results were seen for annual percentage loss (1.9% vs 5.4%, p = 0.034). No difference was observed for lateral tibial cartilage change and annual change (p = 0.98, 0.87 respectively)
Conclusions: Low dose aspirin use was associated with reduced medial tibial cartilage loss over 2 years in people with knee osteoarthritis. This data is hypothesis generating and clinical trials are required to confirm efficacy. If this hypothesis is confirmed, low dose aspirin may be used to reduce the progression of knee osteoarthritis.
|Item Type:||Refereed Article|
|Keywords:||aspirin, cartilage, cohort study, osteoarthritis|
|Research Division:||Medical and Health Sciences|
|Research Group:||Clinical Sciences|
|Research Field:||Rheumatology and Arthritis|
|Objective Group:||Clinical Health (Organs, Diseases and Abnormal Conditions)|
|Objective Field:||Skeletal System and Disorders (incl. Arthritis)|
|Author:||Ding, C (Professor Chang-Hai Ding)|
|Author:||Jones, G (Professor Graeme Jones)|
|Web of Science® Times Cited:||2|
|Deposited By:||Menzies Institute for Medical Research|
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