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Improving the efficiency of the development of drugs for stroke
Citation
Howells, DW and Sena, ES and O'Collins, V and Macleod, MR, Improving the efficiency of the development of drugs for stroke, International Journal of Stroke, 7, (5) pp. 371-377. ISSN 1747-4930 (2012) [Refereed Article]
DOI: doi:10.1111/j.1747-4949.2012.00805.x
Abstract
The mortality and morbidity associated with stroke makes the development of new drugs a research priority. Recent unsuccessful clinical trials have reduced enthusiasm for the development of neuroprotective drugs. Here, we use empirical evidence derived from systematic reviews of stroke drug development to identify stages of drug development which might be improved. We then propose exemplar strategies which may be helpful, along with some basic economic modelling of what the impact of such strategies might be. This suggests that relatively straightforward measures might reduce the costs of drug development by $5·8bn or 31%.
Item Details
| Item Type: | Refereed Article |
|---|---|
| Keywords: | Neuroprotection; Pharmacoecomonics; Translation |
| Research Division: | Medical and Health Sciences |
| Research Group: | Neurosciences |
| Research Field: | Neurology and Neuromuscular Diseases |
| Objective Division: | Health |
| Objective Group: | Clinical Health (Organs, Diseases and Abnormal Conditions) |
| Objective Field: | Nervous System and Disorders |
| Author: | Howells, DW (Professor David Howells) |
| ID Code: | 101072 |
| Year Published: | 2012 |
| Web of Science® Times Cited: | 26 |
| Deposited By: | Office of the School of Medicine |
| Deposited On: | 2015-06-09 |
| Last Modified: | 2017-11-06 |
| Downloads: | 0 |
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