eCite Digital Repository

Composite outcome measures in a pragmatic clinical trial of chronic heart failure management: A comparative assessment

Citation

Chang, S and Davidson, PM and Newton, PJ and Macdonald, P and Carrington, MJ and Marwick, TH and Horowitz, JD and Krum, H and Reid, CM and Chan, YK and Scuffham, PA and Sibbritt, D and Stewart, S, On behalf of the WHICH Investigators, Composite outcome measures in a pragmatic clinical trial of chronic heart failure management: A comparative assessment, International Journal of Cardiology, 185 pp. 62-68. ISSN 0167-5273 (2015) [Refereed Article]

Copyright Statement

2015 Elsevier Ireland Ltd. All rights reserved.

DOI: doi:10.1016/j.ijcard.2015.03.071

Abstract

Background: A number of composite outcomes have been developed to capture the perspective of the patient, clinician and objective measures of health in assessing heart failure outcomes. To date there has been a limited examination in the composition of these outcomes.

Methods and Results: Three commonly used scoring systems in heart failure trials: Packer's composite, Patient Journey and the African American Heart Failure Trial (A-HeFT) scores were compared in assessing outcomes from the Which heart failure intervention is most cost-effective & consumer friendly in reducing hospital care (WHICH(?)) Trial. Comparability and interpretability of these outcomes and the influence of each component to the final outcome were examined. Despite all three composite outcomes incorporating mortality, hospitalisation and quality of life (QoL), the contribution of each individual component to the final outcomes differed. The component with the most influence in deteriorating condition for the Packer's composite was hospitalisation (67.7%), while in Patient Journey it was QoL (61.5%) and for A-HeFT composite score it was mortality (45.4%).

Conclusions: The contribution made by each component varied in subtle, but important ways. This study emphasises the importance of understanding the value system of the composite outcomes to enable meaningful interpretation of results.

Item Details

Item Type:Refereed Article
Keywords:chronic heart failure, composite outcome, outcome assessment
Research Division:Medical and Health Sciences
Research Group:Cardiorespiratory Medicine and Haematology
Research Field:Cardiology (incl. Cardiovascular Diseases)
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Cardiovascular System and Diseases
Author:Marwick, TH (Professor Tom Marwick)
ID Code:101057
Year Published:2015
Web of Science® Times Cited:1
Deposited By:Menzies Institute for Medical Research
Deposited On:2015-06-09
Last Modified:2016-02-18
Downloads:0

Repository Staff Only: item control page