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The influence of stroke risk factors and comorbidities on assessment of stroke therapies in humans and animals
journal contribution
posted on 2023-05-18, 10:40 authored by Ankolekar, S, Rewell, S, David Howells, Bath, PMWThe main driving force behind the assessment of novel pharmacological agents in animal models of stroke is to deliver new drugs to treat the human disease rather than to increase knowledge of stroke pathophysiology. There are numerous animal models of the ischaemic process and it appears that the same processes operate in humans. Yet, despite these similarities, the drugs that appear effective in animal models have not worked in clinical trials. To date, tissue plasminogen activator is the only drug that has been successfully used at the bedside in hyperacute stroke management. Several reasons have been put forth to explain this, but the failure to consider comorbidities and risk factors common in older people is an important one. In this article, we review the impact of the risk factors most studied in animal models of acute stroke and highlight the parallels with human stroke, and, where possible, their influence on evaluation of therapeutic strategies.
History
Publication title
International journal of strokeVolume
7Issue
5Pagination
386-397ISSN
1747-4930Department/School
Tasmanian School of MedicinePublisher
Blackwell PublishersPlace of publication
United KingdomRepository Status
- Restricted