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The influence of stroke risk factors and comorbidities on assessment of stroke therapies in humans and animals


Ankolekar, S and Rewell, S and Howells, DW and Bath, PMW, The influence of stroke risk factors and comorbidities on assessment of stroke therapies in humans and animals, International journal of stroke, 7, (5) pp. 386-397. ISSN 1747-4930 (2012) [Refereed Article]

DOI: doi:10.1111/j.1747-4949.2012.00802.x


The main driving force behind the assessment of novel pharmacological agents in animal models of stroke is to deliver new drugs to treat the human disease rather than to increase knowledge of stroke pathophysiology. There are numerous animal models of the ischaemic process and it appears that the same processes operate in humans. Yet, despite these similarities, the drugs that appear effective in animal models have not worked in clinical trials. To date, tissue plasminogen activator is the only drug that has been successfully used at the bedside in hyperacute stroke management. Several reasons have been put forth to explain this, but the failure to consider comorbidities and risk factors common in older people is an important one. In this article, we review the impact of the risk factors most studied in animal models of acute stroke and highlight the parallels with human stroke, and, where possible, their influence on evaluation of therapeutic strategies.

Item Details

Item Type:Refereed Article
Keywords:acute stroke;animal models;diabetes;hypertension;risk factors;stroke therapies
Research Division:Biomedical and Clinical Sciences
Research Group:Neurosciences
Research Field:Neurology and neuromuscular diseases
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Howells, DW (Professor David Howells)
ID Code:101006
Year Published:2012
Web of Science® Times Cited:28
Deposited By:Office of the School of Medicine
Deposited On:2015-06-05
Last Modified:2017-11-06

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