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β-Adrenergic signaling regulates NR4A nuclear receptor and metabolic gene expression in multiple tissues

Citation

Myers, SA and Eriksson, N and Burrow, R and Wang, S-CM and Muscat, GEO, β-Adrenergic signaling regulates NR4A nuclear receptor and metabolic gene expression in multiple tissues, Molecular and Cellular Endocrinology, 309, (1-2) pp. 101-108. ISSN 0303-7207 (2009) [Refereed Article]

Copyright Statement

Copyright 2009 Elsevier Ireland Ltd.

DOI: doi:10.1016/j.mce.2009.05.006

Abstract

The nuclear hormone receptor (NR) 4A subgroup of orphan nuclear receptors includes three members, Nur77 (NR4A1), Nurr1 (NR4A2) and Nor-1 (NR4A3). Previously we have identified the rapid and robust (in vitro and in vivo) induction of the NR4A subgroup following β-adrenergic stimulation in mouse skeletal muscle. This was concomitant with changes in the expression of genes involved in the regulation of nutrient metabolism. We have isolated mouse tissue of cardiovascular, endocrine and gastrointestinal origin at 1, 4, 8 and 24 h after a single intraperitoneal injection of the β-adrenergic agonist, isoprenaline. We similarly identified the significant induction (between 1 and 4 h) of the NR4A genes in many of these tissues. Moreover, we have utilized TaqManŽ Low Density Arrays to determine the β-adrenergic-sensitive metabolic gene expression in liver, white adipose and heart. In summary, cross-talk between β-adrenergic and NR4A signaling occurs in several tissues, and is accompanied by modulation of metabolic gene expression.

Item Details

Item Type:Refereed Article
Keywords:NR4A nuclear Receptors
Research Division:Biological Sciences
Research Group:Biochemistry and Cell Biology
Research Field:Cell Metabolism
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Diabetes
Author:Myers, SA (Dr Stephen Myers)
ID Code:100975
Year Published:2009
Web of Science® Times Cited:43
Deposited By:Health Sciences B
Deposited On:2015-06-04
Last Modified:2015-09-18
Downloads:0

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