eCite Digital Repository
β-Adrenergic signaling regulates NR4A nuclear receptor and metabolic gene expression in multiple tissues
Myers, SA and Eriksson, N and Burrow, R and Wang, S-CM and Muscat, GEO, β-Adrenergic signaling regulates NR4A nuclear receptor and metabolic gene expression in multiple tissues, Molecular and Cellular Endocrinology, 309, (1-2) pp. 101-108. ISSN 0303-7207 (2009) [Refereed Article]
Copyright 2009 Elsevier Ireland Ltd.
The nuclear hormone receptor (NR) 4A subgroup of orphan nuclear receptors includes three members, Nur77 (NR4A1), Nurr1 (NR4A2) and Nor-1 (NR4A3). Previously we have identified the rapid and robust (in vitro and in vivo) induction of the NR4A subgroup following β-adrenergic stimulation in mouse skeletal muscle. This was concomitant with changes in the expression of genes involved in the regulation of nutrient metabolism. We have isolated mouse tissue of cardiovascular, endocrine and gastrointestinal origin at 1, 4, 8 and 24 h after a single intraperitoneal injection of the β-adrenergic agonist, isoprenaline. We similarly identified the significant induction (between 1 and 4 h) of the NR4A genes in many of these tissues. Moreover, we have utilized TaqManŽ Low Density Arrays to determine the β-adrenergic-sensitive metabolic gene expression in liver, white adipose and heart. In summary, cross-talk between β-adrenergic and NR4A signaling occurs in several tissues, and is accompanied by modulation of metabolic gene expression.
|Item Type:||Refereed Article|
|Keywords:||NR4A nuclear Receptors|
|Research Division:||Biological Sciences|
|Research Group:||Biochemistry and cell biology|
|Research Field:||Cell metabolism|
|Objective Group:||Clinical health|
|Objective Field:||Clinical health not elsewhere classified|
|UTAS Author:||Myers, SA (Dr Stephen Myers)|
|Web of Science® Times Cited:||66|
|Deposited By:||Health Sciences B|
Repository Staff Only: item control page