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Exercise excess pressure and exercise-induced albuminuria in patients with type 2 diabetes mellitus
Citation
Climie, RED and Srikanth, V and Keith, LJ and Davies, JE and Sharman, JE, Exercise excess pressure and exercise-induced albuminuria in patients with type 2 diabetes mellitus, American Journal of Physiology: Heart and Circulatory Physiology, 308, (9) pp. H1136-H1142. ISSN 0363-6135 (2015) [Refereed Article]
Copyright Statement
Copyright 2015 American Physiological Society
DOI: doi:10.1152/ajpheart.00739.2014
Abstract
Exercise-induced albuminuria is common in patients with type 2 diabetes mellitus (T2DM) in response to maximal exercise, but the response to light-moderate exercise is unclear. Patients with T2DM have abnormal central hemodynamics and greater propensity for exercise hypertension. This study sought to determine the relationship between light-moderate exercise central hemodynamics (including aortic reservoir and excess pressure) and exercise-induced albuminuria. Thirty-nine T2DM (62 ± 9 yr; 49% male) and 39 nondiabetic controls (53 ± 9 yr; 51% male) were examined at rest and during 20 min of light-moderate cycle exercise (30 W; 50 revolutions/min). Albuminuria was assessed by the albumin-creatinine ratio (ACR) at rest and 30 min postexercise. Hemodynamics recorded included brachial and central blood pressure (BP), aortic stiffness, augmented pressure (AP), aortic reservoir pressure, and excess pressure integral (Pexcess). There was no difference in ACR between groups before exercise (P > 0.05). Exercise induced a significant rise in ACR in T2DM but not controls (1.73 ± 1.43 vs. 0.53 ± 1.0 mg/mol, P = 0.002). All central hemodynamic variables were significantly higher during exercise in T2DM (i.e., Pexcess, systolic BP and AP; P < 0.01 all). In T2DM (but not controls), exercise Pexcess was associated with postexercise ACR (r = 0.51, P = 0.002), and this relationship was independent of age, sex, body mass index, heart rate, aortic stiffness, antihypertensive medication, and ambulatory daytime systolic BP (β = 0.003, P = 0.003). Light-moderate exercise induced a significant rise in ACR in T2DM, and this was independently associated with Pexcess, a potential marker of vascular dysfunction. These novel findings suggest that Pexcess could be important for appropriate renal function in T2DM.
Item Details
Item Type: | Refereed Article |
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Keywords: | exercise blood pressure, physiology, renal dysfunction |
Research Division: | Biomedical and Clinical Sciences |
Research Group: | Cardiovascular medicine and haematology |
Research Field: | Cardiology (incl. cardiovascular diseases) |
Objective Division: | Health |
Objective Group: | Clinical health |
Objective Field: | Clinical health not elsewhere classified |
UTAS Author: | Climie, RED (Dr Rachel Climie) |
UTAS Author: | Srikanth, V (Dr Velandai Srikanth) |
UTAS Author: | Keith, LJ (Miss Laura Keith) |
UTAS Author: | Sharman, JE (Professor James Sharman) |
ID Code: | 100970 |
Year Published: | 2015 |
Web of Science® Times Cited: | 28 |
Deposited By: | Menzies Institute for Medical Research |
Deposited On: | 2015-06-04 |
Last Modified: | 2017-11-01 |
Downloads: | 0 |
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