University of Tasmania
Browse

File(s) not publicly available

The cellular mechanism underlying neuronal degeneration in glaucoma: Parallels with Alzheimer's disease

journal contribution
posted on 2023-05-16, 10:27 authored by James VickersJames Vickers
Evidence is presented that the characteristic pattern of neutonal degeneration associated with glaucoma is due to a combination of the persistent physical damage to axons at the level of the lamina cribrosa and the associated neuronal reaction to this kind of trauma. The class of neuronal cytoskeletal proteins known as the neurofilament triplet are crucially involved in the reaction to physical damage and the selective localization of these proteins to larger retinal ganglion cells may underlie their susceptibility to eventual degeneration. The appearance of glaucoma- like neuronal pathology in Alzheimer's disease may follow the reaction of neurofilamentcontaining retinal ganglion neurons to persistent damage to their axons by β-amyloid plaque formation in subcortical visual centres.

History

Publication title

Australian and New Zealand Journal of Ophthalmology

Volume

25

Pagination

105-109

ISSN

0814-9763

Department/School

Tasmanian School of Medicine

Publisher

Wiley-Blackwell Publishing Asia

Place of publication

Australia

Repository Status

  • Restricted

Socio-economic Objectives

Clinical health not elsewhere classified

Usage metrics

    University Of Tasmania

    Categories

    Exports

    RefWorks
    BibTeX
    Ref. manager
    Endnote
    DataCite
    NLM
    DC