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The cellular mechanism underlying neuronal degeneration in glaucoma: Parallels with Alzheimer's disease
Citation
Vickers, JC, The cellular mechanism underlying neuronal degeneration in glaucoma: Parallels with Alzheimer's disease, Australian and New Zealand Journal of Ophthalmology, 25, (2) pp. 105-109. ISSN 0814-9763 (1997) [Refereed Article]
DOI: doi:10.1111/j.1442-9071.1997.tb01290.x
Abstract
Evidence is presented that the characteristic pattern of neutonal degeneration associated with glaucoma is due to a combination of the persistent physical damage to axons at the level of the lamina cribrosa and the associated neuronal reaction to this kind of trauma. The class of neuronal cytoskeletal proteins known as the neurofilament triplet are crucially involved in the reaction to physical damage and the selective localization of these proteins to larger retinal ganglion cells may underlie their susceptibility to eventual degeneration. The appearance of glaucoma- like neuronal pathology in Alzheimer's disease may follow the reaction of neurofilamentcontaining retinal ganglion neurons to persistent damage to their axons by β-amyloid plaque formation in subcortical visual centres.
Item Details
Item Type: | Refereed Article |
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Research Division: | Biomedical and Clinical Sciences |
Research Group: | Ophthalmology and optometry |
Research Field: | Ophthalmology |
Objective Division: | Health |
Objective Group: | Clinical health |
Objective Field: | Clinical health not elsewhere classified |
UTAS Author: | Vickers, JC (Professor James Vickers) |
ID Code: | 10094 |
Year Published: | 1997 |
Web of Science® Times Cited: | 32 |
Deposited By: | Pathology |
Deposited On: | 1997-08-01 |
Last Modified: | 2015-07-31 |
Downloads: | 0 |
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