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Magnocellular and parvocellular visual pathways are both affected in a macaque monkey model of glaucoma
Citation
Vickers, JC and Hof, PR and Schumer, RA and Wang, RT and Podos, SM and Morrison, JH, Magnocellular and parvocellular visual pathways are both affected in a macaque monkey model of glaucoma, Australian and New Zealand Journal of Opthalmology, 25, (3) pp. 239-243. ISSN 0814-9763 (1997) [Refereed Article]
DOI: doi:10.1111/j.1442-9071.1997.tb01400.x
Abstract
Purpose: Neurochemical changes in nerve cells were investigated in the lateral geniculate nucleus (LGN) and primary visual cortex of macaque monkeys with experimentally induced glaucoma. Methods: Glaucomatous damage was induced in one eye of experimental animals by elevation of intraocular pressure following laser burns to the trabecular meshwork. Staining for the metabolic marker cytochrome oxidase, as well as immunolabelling for the neuronal markers synaptophysin and neurofilament proteins, was conducted on sections of the LGN and primary visual cortex. Results: In the LGN, staining for cytochrome oxidase and immunolabelling for synaptophysin were reduced in the parvocellular and magnocellular layers that received input from the glaucomatous eye and neurofilament protein labelling was reduced in the parvocellular layers. Cytochrome oxidase staining demonstrated the presence of denervated ocular dominance columns in layer IVC of the primary visual cortex of experimental animals. Conclusions: Pre-and post-synaptic neurochemical alterations in the magnocellular and parvocellular visual path- ways of the brain are associated with experimentally induced glaucoma in macaque monkeys.
Item Details
Item Type: | Refereed Article |
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Research Division: | Biomedical and Clinical Sciences |
Research Group: | Ophthalmology and optometry |
Research Field: | Ophthalmology |
Objective Division: | Health |
Objective Group: | Clinical health |
Objective Field: | Clinical health not elsewhere classified |
UTAS Author: | Vickers, JC (Professor James Vickers) |
ID Code: | 10093 |
Year Published: | 1997 |
Web of Science® Times Cited: | 58 |
Deposited By: | Pathology |
Deposited On: | 1997-08-01 |
Last Modified: | 2011-08-11 |
Downloads: | 0 |
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