Purpose: Neurochemical changes in nerve cells were investigated in the lateral geniculate nucleus (LGN) and primary visual cortex of macaque monkeys with experimentally induced glaucoma. Methods: Glaucomatous damage was induced in one eye of experimental animals by elevation of intraocular pressure following laser burns to the trabecular meshwork. Staining for the metabolic marker cytochrome oxidase, as well as immunolabelling for the neuronal markers synaptophysin and neurofilament proteins, was conducted on sections of the LGN and primary visual cortex. Results: In the LGN, staining for cytochrome oxidase and immunolabelling for synaptophysin were reduced in the parvocellular and magnocellular layers that received input from the glaucomatous eye and neurofilament protein labelling was reduced in the parvocellular layers. Cytochrome oxidase staining demonstrated the presence of denervated ocular dominance columns in layer IVC of the primary visual cortex of experimental animals. Conclusions: Pre-and post-synaptic neurochemical alterations in the magnocellular and parvocellular visual path- ways of the brain are associated with experimentally induced glaucoma in macaque monkeys.

Item Type:	Refereed Article
Research Division:	Medical and Health Sciences
Research Group:	Ophthalmology and Optometry
Research Field:	Ophthalmology
Objective Division:	Health
Objective Group:	Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:	Hearing, Vision, Speech and Their Disorders
Author:	Vickers, JC (Professor James Vickers)
ID Code:	10093
Year Published:	1997
Web of Science® Times Cited:	54
Deposited By:	Pathology
Deposited On:	1997-08-01
Last Modified:	2011-08-11
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