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The Influence of Living Near Roadways on Spirometry and Exhaled Nitric Oxide in Elementary Schoolchildren

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Dales, R and Wheeler, A and Mahmud, M and Frescura, AM and Smith-Doiron, M and Nethery, E and Liu, L, The Influence of Living Near Roadways on Spirometry and Exhaled Nitric Oxide in Elementary Schoolchildren, Environmental Health Perspectives, 116 pp. 1423-1427. ISSN 0091-6765 (2008) [Refereed Article]


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DOI: doi:10.1289/ehp.10943

Abstract

BACKGROUND: Living near major roadways has been associated with an increase in respiratory symptoms, but little is known about how this relates to airway inflammation.

OBJECTIVE: We assessed the effects of living near local residential roadways based on objective indicators of ventilatory function and airway inflammation.

METHODS: We estimated ambient air pollution, resolved to the level of the child's neighborhood, using a land-use regression model for children 9-11 years of age. We also summed the length of roadways found within a 200-m radius of each child's neighborhood. We had measurements of both air pollution exposure and spirometry for 2,328 children, and also had measurements of exhaled nitric oxide (eNO) for 1,613 of these children.

RESULTS: Each kilometer of local roadway within a 200-m radius of the home was associated with a 6.8% increase in eNO (p = 0.045). Each kilometer of any type of roadway (local, major, highway) was also associated with an increase in eNO of 10.1% (p = 0.002). Each microgram per cubic meter increase in PM2.5 was associated with a 3.9% increase in eNO (p = 0.058) and 0.70% decrease in forced vital capacity (FVC) expressed as a percentage of predicted (p = 0.39). Associations between roadway density and both forced expired volume in 1 sec and FVC were negative but not statistically significant at p < 0.05.

CONCLUSION: Traffic from local neighborhood roadways may cause airway inflammation as indicated by eNO. This may be a more sensitive indicator of adverse air pollution effects than traditional measures of ventilatory function.

Item Details

Item Type:Refereed Article
Keywords:air quality, respiratory health, children
Research Division:Medical and Health Sciences
Research Group:Public Health and Health Services
Research Field:Environmental and Occupational Health and Safety
Objective Division:Health
Objective Group:Public Health (excl. Specific Population Health)
Objective Field:Environmental Health
Author:Wheeler, A (Dr Amanda Wheeler)
ID Code:100887
Year Published:2008
Web of Science® Times Cited:50
Deposited By:Menzies Institute for Medical Research
Deposited On:2015-06-02
Last Modified:2015-09-14
Downloads:209 View Download Statistics

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