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Influence of Personal Exposure to Particulate Air Pollution on Cardiovascular Physiology and Biomarkers of Inflammation and Oxidative Stress in Subjects With Diabetes

Citation

Liu, L and Ruddy, TD and Dalipaj, M and Szyszkowicz, M and You, H and Poon, R and Wheeler, A and Dales, R, Influence of Personal Exposure to Particulate Air Pollution on Cardiovascular Physiology and Biomarkers of Inflammation and Oxidative Stress in Subjects With Diabetes, Journal of Occupational and Environmental Medicine, 49 pp. 258-265. ISSN 1076-2752 (2007) [Refereed Article]

Copyright Statement

Copyright 2007 by American College of Occupational and Environmental Medicine

DOI: doi:10.1097/JOM.0b013e31803220ef

Abstract

Objective: We investigated whether personal exposure to particulate matter 10 m in diameter (PM10) contributes to impaired cardiovascular function and increased systemic inflammation and oxidative stress in diabetic patients.

Methods: We monitored 25 patientsí personal exposure to PM10 for 24 hours and then measured their heart rate, blood pressure, brachial arterial diameter, flow-mediated vasodilation (FMD), plasma cytokines, and thiobarbituric acid reactive substances (TBARS), which is an oxidative stress marker. We repeated this procedure for 7 weeks on each subject. We tested the associations using mixed-effects models.

Results: PM10 was significantly positively associated with FMD and TBARS but inversely associated with end-systolic basal brachial arterial diameter (P  0.05). Moreover, in subjects not taking vasoactive medications, PM10 was significantly positively associated with blood pressure but inversely associated with artery flow.

Conclusion: Elevated PM10 may contribute to oxidative stress and impaired cardiovascular function in patients with diabetes mellitus.

Item Details

Item Type:Refereed Article
Keywords:personal exposure, air quality, cardiovascular health
Research Division:Medical and Health Sciences
Research Group:Public Health and Health Services
Research Field:Environmental and Occupational Health and Safety
Objective Division:Health
Objective Group:Public Health (excl. Specific Population Health)
Objective Field:Environmental Health
Author:Wheeler, A (Dr Amanda Wheeler)
ID Code:100880
Year Published:2007
Web of Science® Times Cited:49
Deposited By:Menzies Institute for Medical Research
Deposited On:2015-06-02
Last Modified:2015-09-09
Downloads:0

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