Liu, L and Ruddy, TD and Dalipaj, M and Szyszkowicz, M and You, H and Poon, R and Wheeler, A and Dales, R, Influence of Personal Exposure to Particulate Air Pollution on Cardiovascular Physiology and Biomarkers of Inflammation and Oxidative Stress in Subjects With Diabetes, Journal of Occupational and Environmental Medicine, 49 pp. 258-265. ISSN 1076-2752 (2007) [Refereed Article]
Copyright 2007 by American College of Occupational and Environmental Medicine
Methods: We monitored 25 patientsí personal exposure to PM10 for 24 hours and then measured their heart rate, blood pressure, brachial arterial diameter, flow-mediated vasodilation (FMD), plasma cytokines, and thiobarbituric acid reactive substances (TBARS), which is an oxidative stress marker. We repeated this procedure for 7 weeks on each subject. We tested the associations using mixed-effects models.
Results: PM10 was significantly positively associated with FMD and TBARS but inversely associated with end-systolic basal brachial arterial diameter (P 0.05). Moreover, in subjects not taking vasoactive medications, PM10 was significantly positively associated with blood pressure but inversely associated with artery flow.
Conclusion: Elevated PM10 may contribute to oxidative stress and impaired cardiovascular function in patients with diabetes mellitus.
|Item Type:||Refereed Article|
|Keywords:||personal exposure, air quality, cardiovascular health|
|Research Division:||Medical and Health Sciences|
|Research Group:||Public Health and Health Services|
|Research Field:||Environmental and Occupational Health and Safety|
|Objective Group:||Public Health (excl. Specific Population Health)|
|Objective Field:||Environmental Health|
|Author:||Wheeler, A (Dr Amanda Wheeler)|
|Web of Science® Times Cited:||52|
|Deposited By:||Menzies Institute for Medical Research|
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