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Border between natural product and drug: comparison of the related benzoquinones idebenone and coenzyme Q10

Citation

Gueven, N and Woolley, K and Smith, J, Border between natural product and drug: comparison of the related benzoquinones idebenone and coenzyme Q10, Redox Biology, 4 pp. 289-295. ISSN 2213-2317 (2015) [Refereed Article]

Copyright Statement

2015 Elsevier B.V. Published by Elsevier B.V. All rights reserved.

DOI: doi:10.1016/j.redox.2015.01.009

Abstract

Coenzyme Q10 is a ubiquitous component of cellular membranes and belongs to the class of benzoquinones that mainly differ with regards to the length and composition of their hydrophobic tail. The characteristic quinone group can accept electrons from various biological sources and is converted by a one electron transfer to the unstable semiquinone or by a two electron transfer to the more stable hydroquinone. This feature makes CoQ10 the bona fide cellular electron transfer molecule within the mitochondrial respiratory chain and also makes it a potent cellular antioxidant. These activities serve as justification for its popular use as food supplement. Another quinone with similarities to the naturally occurring CoQ10 is idebenone, which shares its quinone moiety with CoQ10, but at the same time differs from CoQ10 by the presence of a much shorter, less lipophilic tail. However, despite its similarity to CoQ10, idebenone cannot be isolated from any natural sources but instead was synthesized and selected as a pharmacologically active compound in the 1980s by Takeda Pharmaceuticals purely based on its pharmacological properties. Several recent clinical trials demonstrated some therapeutic efficacy of idebenone in different indications and as a consequence, many practitioners question if the freely available CoQ10 could not be used instead. Here, we describe the molecular and pharmacological features of both molecules that arise from their structural differences to answer the question if idebenone is merely a CoQ10 analogue as frequently perpetuated in the literature or a pharmaceutical drug with entirely different features.

Item Details

Item Type:Refereed Article
Keywords:benzoquinone, idebenone, coenzyme Q10, mitochondria, antioxidant
Research Division:Medical and Health Sciences
Research Group:Pharmacology and Pharmaceutical Sciences
Research Field:Basic Pharmacology
Objective Division:Expanding Knowledge
Objective Group:Expanding Knowledge
Objective Field:Expanding Knowledge in the Medical and Health Sciences
Author:Gueven, N (Associate Professor Nuri Gueven)
Author:Woolley, K (Miss Krystel Woolley)
Author:Smith, J (Associate Professor Jason Smith)
ID Code:100745
Year Published:2015
Deposited By:Chemistry
Deposited On:2015-05-27
Last Modified:2016-05-17
Downloads:0

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