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Systematic reviews and meta-analysis of preclinical studies: why perform them and how to appraise them critically

Citation

Sena, ES and Currie, GL and McCann, SK and Macleod, MR and Howells, DW, Systematic reviews and meta-analysis of preclinical studies: why perform them and how to appraise them critically, Journal of Cerebral Blood Flow and Metabolism, 34 pp. 737-742. ISSN 0271-678X (2014) [Refereed Article]

DOI: doi:10.1038/jcbfm.2014.28

Abstract

The use of systematic review and meta-analysis of preclinical studies has become more common, including those of studies describing the modeling of cerebrovascular diseases. Empirical evidence suggests that too many preclinical experiments lack methodological rigor, and this leads to inflated treatment effects. The aim of this review is to describe the concepts of systematic review and meta-analysis and consider how these tools may be used to provide empirical evidence to spur the field to improve the rigor of the conduct and reporting of preclinical research akin to their use in improving the conduct and reporting of randomized controlled trials in clinical research. As with other research domains, systematic reviews are subject to bias. Therefore, we have also suggested guidance for their conduct, reporting, and critical appraisal.

Item Details

Item Type:Refereed Article
Keywords:acute stroke; animal models; basic science; Biostatistics; experimental
Research Division:Medical and Health Sciences
Research Group:Clinical Sciences
Research Field:Clinical Sciences not elsewhere classified
Objective Division:Expanding Knowledge
Objective Group:Expanding Knowledge
Objective Field:Expanding Knowledge in the Medical and Health Sciences
Author:Howells, DW (Professor David Howells)
ID Code:100736
Year Published:2014
Web of Science® Times Cited:45
Deposited By:Office of the School of Medicine
Deposited On:2015-05-27
Last Modified:2017-11-06
Downloads:0

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