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Fish oil diet associated with acute reperfusion related hemorrhage, and with reduced stroke-related sickness behaviors and motor impairment

journal contribution
posted on 2023-05-18, 10:20 authored by Pascoe, MC, David Howells, Crewther, DP, Constantinou, N, Carey, LM, Rewell, SS, Turchini, GM, Kaur, G, Crewther, SG
schemic stroke is associated with motor impairment and increased incidence of affective disorders such as anxiety/clinical depression. In non-stroke populations, successful management of such disorders and symptoms has been reported following diet supplementation with long chain omega-3-polyunsaturated-fatty-acids (PUFAs). However, the potential protective effects of PUFA supplementation on affective behaviors after experimentally induced stroke and sham surgery have not been examined previously. This study investigated the behavioral effects of PUFA supplementation over a 6-week period following either middle cerebral artery occlusion or sham surgery in the hooded-Wistar rat. The PUFA diet supplied during the acclimation period prior to surgery was found to be associated with an increased risk of acute hemorrhage following the reperfusion component of the surgery. In surviving animals, PUFA supplementation did not influence infarct size as determined 6 weeks after surgery, but did decrease omega-6-fatty-acid levels, moderate sickness behaviors, acute motor impairment, and longer-term locomotor hyperactivity and depression/anxiety-like behavior.

History

Publication title

Frontiers in Neurology

Volume

5

Article number

14

Number

14

Pagination

1-15

ISSN

1664-2295

Department/School

Tasmanian School of Medicine

Publisher

Frontiers Research Foundation

Place of publication

Switzerland

Repository Status

  • Restricted

Socio-economic Objectives

Clinical health not elsewhere classified

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