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Fish oil diet associated with acute reperfusion related hemorrhage, and with reduced stroke-related sickness behaviors and motor impairment

Citation

Pascoe, MC and Howells, DW and Crewther, DP and Constantinou, N and Carey, LM and Rewell, SS and Turchini, GM and Kaur, G and Crewther, SG, Fish oil diet associated with acute reperfusion related hemorrhage, and with reduced stroke-related sickness behaviors and motor impairment, Frontiers in Neurology, 5 Article 14. ISSN 1664-2295 (2014) [Refereed Article]

DOI: doi:10.3389/fneur.2014.00014

Abstract

schemic stroke is associated with motor impairment and increased incidence of affective disorders such as anxiety/clinical depression. In non-stroke populations, successful management of such disorders and symptoms has been reported following diet supplementation with long chain omega-3-polyunsaturated-fatty-acids (PUFAs). However, the potential protective effects of PUFA supplementation on affective behaviors after experimentally induced stroke and sham surgery have not been examined previously. This study investigated the behavioral effects of PUFA supplementation over a 6-week period following either middle cerebral artery occlusion or sham surgery in the hooded-Wistar rat. The PUFA diet supplied during the acclimation period prior to surgery was found to be associated with an increased risk of acute hemorrhage following the reperfusion component of the surgery. In surviving animals, PUFA supplementation did not influence infarct size as determined 6 weeks after surgery, but did decrease omega-6-fatty-acid levels, moderate sickness behaviors, acute motor impairment, and longer-term locomotor hyperactivity and depression/anxiety-like behavior.

Item Details

Item Type:Refereed Article
Keywords:Middle-cerebral-artery-occlusion; Mood; Polyunsaturated fatty acids; Stroke
Research Division:Medical and Health Sciences
Research Group:Neurosciences
Research Field:Neurosciences not elsewhere classified
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Nervous System and Disorders
Author:Howells, DW (Professor David Howells)
ID Code:100705
Year Published:2014
Web of Science® Times Cited:3
Deposited By:Medicine (Discipline)
Deposited On:2015-05-26
Last Modified:2017-11-06
Downloads:0

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