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Exposure to parental smoking in childhood is associated with increased risk of carotid atherosclerotic plaque in adulthood: the Cardiovascular Risk in Young Finns Study

Citation

West, HW and Juonala, M and Gall, SL and Kahonen, M and Laitinen, T and Taittonen, L and Viikari, JSA and Raitakari, OT and Magnussen, CG, Exposure to parental smoking in childhood is associated with increased risk of carotid atherosclerotic plaque in adulthood: the Cardiovascular Risk in Young Finns Study, Circulation, 131, (14) pp. 1239-1246. ISSN 0009-7322 (2015) [Refereed Article]

Copyright Statement

Copyright 2015 American Heart Association, Inc.

DOI: doi:10.1161/CIRCULATIONAHA.114.013485

Abstract

Background: The association between passive smoking exposure in childhood and adverse cardiovascular health in adulthood is not well understood. Using a 26-year follow-up study, we examined whether childhood exposure to passive smoking was associated with carotid atherosclerotic plaque in young adults.

Methods and Results: Participants were from the Cardiovascular Risk in Young Finns Study (n = 2448). Information on childhood exposure to parental smoking was collected in 1980 and 1983. Carotid ultrasound data were collected in adulthood in 2001 or 2007. Childhood serum cotinine levels from 1980 were measured from frozen samples in 2014 (n = 1578). The proportion of children with nondetectable cotinine levels was highest among households in which neither parent smoked (84%), was decreased in households in which 1 parent smoked (62%), and was lowest among households in which both parents smoked (43%). Regardless of adjustment for potential confounding and mediating variables, the relative risk of developing carotid plaque in adulthood increased among those children with 1 or both parents who smoked (relative risk, 1.7; 95% confidence interval, 1.0-2.8; P = 0.04). Although children whose parents exercised good "smoking hygiene" (smoking parents whose children had nondetectable cotinine levels) had increased risk of carotid plaque compared with children with nonsmoking parents (relative risk, 1.6; 95% confidence interval, 0.6-4.0; P = 0.34), children of smoking parents with poor smoking hygiene (smoking parents whose children had detectable serum cotinine levels) had substantially increased risk of plaque as adults (relative risk, 4.0; 95% confidence interval, 1.7-9.8; P = 0.002).

Conclusions: Children of parents who smoke have increased risk of developing carotid atherosclerotic plaque in adulthood. However, parents who exercise good smoking hygiene can lessen their child's risk of developing plaque.

Item Details

Item Type:Refereed Article
Keywords:child, epidemiology, plaque, atherosclerotic, risk factors, tobacco smoke pollution
Research Division:Medical and Health Sciences
Research Group:Public Health and Health Services
Research Field:Epidemiology
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Cardiovascular System and Diseases
Author:West, HW (Mr Henry West)
Author:Gall, SL (Dr Seana Gall)
Author:Magnussen, CG (Dr Costan Magnussen)
ID Code:100692
Year Published:2015
Web of Science® Times Cited:15
Deposited By:Menzies Institute for Medical Research
Deposited On:2015-05-26
Last Modified:2016-02-16
Downloads:0

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