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Non-anticoagulant derivatives of heparin for the management of asthma: distant dream or close reality?


Shastri, M and Peterson, GM and Stewart, NJ and Sohal, SS and Patel, RP, Non-anticoagulant derivatives of heparin for the management of asthma: distant dream or close reality?, Expert Opinion on Investigational Drugs: Authoritative Analysis of Randd Trends, 23, (3) pp. 357-373. ISSN 1354-3784 (2014) [Refereed Article]

DOI: doi:10.1517/13543784.2014.866092


Introduction: Approximately 300 million people worldwide are currently affected by asthma. Improvements in the understanding of the mechanisms involved in such inflammatory airway disorders has led to the recognition of new therapeutic approaches. Heparin, a widely used anticoagulant, has been shown to be beneficial in the management of asthma. It belongs to the family of highly sulphated polysaccharides referred to as glycosaminoglycans, containing a heterogeneous mixture of both anticoagulant and non-anticoagulant polysaccharides. Experimental findings have suggested that heparin has potential anti-asthmatic properties owing to the ability of its non-anticoagulant oligosaccharides to bind and modulate the activity of a wide range of biological molecules involved in the inflammatory process.

Areas covered: This review focuses on the potential mechanisms of action and clinical application of heparin as an anti-inflammatory agent for the management of asthma.

Expert opinion: Heparin may play a significant role in the management of asthma. However, these properties are often hindered by the presence of anticoagulant oligosaccharides, which possess a significant risk of bleeding. Therefore, its therapeutic potential must be explored using well-designed clinical studies that focus on identifying and isolating the anti-inflammatory oligosaccharides of heparin and further elucidating the structure and mechanisms of actions of these non-anticoagulant oligosaccharides.

Item Details

Item Type:Refereed Article
Keywords:anticoagulant oligosaccharides, anti-inflammatory, asthma, bleeding, heparin, low molecular weight heparin, non-anticoagulant oligosaccharides
Research Division:Biomedical and Clinical Sciences
Research Group:Cardiovascular medicine and haematology
Research Field:Respiratory diseases
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Shastri, M (Mr Madhur Shastri)
UTAS Author:Peterson, GM (Professor Gregory Peterson)
UTAS Author:Stewart, NJ (Dr Niall Stewart)
UTAS Author:Sohal, SS (Dr Sukhwinder Sohal)
UTAS Author:Patel, RP (Dr Rahul Patel)
ID Code:100454
Year Published:2014
Web of Science® Times Cited:14
Deposited By:Pharmacy
Deposited On:2015-05-18
Last Modified:2017-11-02

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