Shastri, M and Peterson, GM and Stewart, NJ and Sohal, SS and Patel, RP, Non-anticoagulant derivatives of heparin for the management of asthma: distant dream or close reality?, Expert Opinion on Investigational Drugs: Authoritative Analysis of Randd Trends, 23, (3) pp. 357-373. ISSN 1354-3784 (2014) [Refereed Article]
Introduction: Approximately 300 million people worldwide are currently affected by asthma. Improvements in the understanding of the mechanisms involved in such inflammatory airway disorders has led to the recognition of new therapeutic approaches. Heparin, a widely used anticoagulant, has been shown to be beneficial in the management of asthma. It belongs to the family of highly sulphated polysaccharides referred to as glycosaminoglycans, containing a heterogeneous mixture of both anticoagulant and non-anticoagulant polysaccharides. Experimental findings have suggested that heparin has potential anti-asthmatic properties owing to the ability of its non-anticoagulant oligosaccharides to bind and modulate the activity of a wide range of biological molecules involved in the inflammatory process.
Areas covered: This review focuses on the potential mechanisms of action and clinical application of heparin as an anti-inflammatory agent for the management of asthma.
Expert opinion: Heparin may play a significant role in the management of asthma. However, these properties are often hindered by the presence of anticoagulant oligosaccharides, which possess a significant risk of bleeding. Therefore, its therapeutic potential must be explored using well-designed clinical studies that focus on identifying and isolating the anti-inflammatory oligosaccharides of heparin and further elucidating the structure and mechanisms of actions of these non-anticoagulant oligosaccharides.
|Item Type:||Refereed Article|
|Keywords:||anticoagulant oligosaccharides, anti-inflammatory, asthma, bleeding, heparin, low molecular weight heparin, non-anticoagulant oligosaccharides|
|Research Division:||Medical and Health Sciences|
|Research Group:||Cardiorespiratory Medicine and Haematology|
|Research Field:||Respiratory Diseases|
|Objective Group:||Clinical Health (Organs, Diseases and Abnormal Conditions)|
|Objective Field:||Respiratory System and Diseases (incl. Asthma)|
|Author:||Shastri, M (Mr Madhur Shastri)|
|Author:||Peterson, GM (Professor Gregory Peterson)|
|Author:||Stewart, NJ (Dr Niall Stewart)|
|Author:||Sohal, SS (Dr Sukhwinder Sohal)|
|Author:||Patel, RP (Dr Rahul Patel)|
|Web of Science® Times Cited:||12|
Repository Staff Only: item control page