Fassett, RG and Robertson, IK and Ball, MJ and Geraghty, DP and Coombes, JS, Effect of atorvastatin on oxidative stress in chronic kidney disease: a sub-study of the Lipid lowering and Onset of Renal Disease (LORD) Trial, Nephrology, 20 ISSN 1440-1797 (2015) [Refereed Article]
Aim: Statins have pleiotropic effects that include attenuation of oxidative stress that may be relevant for CKD patients. We investigated the effect of long term atorvastatin therapy on oxidative stress biomarkers in CKD patients.
Methods: This was a pre-specified secondary analysis of data from a randomized, double-blind, placebo-controlled trial (LORD) in CKD patients. Participants received 10 mg/day atorvastatin (n=47) or placebo (n=39) for three-years. Plasma measures (total F2-isoprostanes, malondialdehyde. protein carbonyls, uric acid, glutathione peroxidase (GPx) activity and total antioxidant capacity (TAC)) were performed at baseline and at three years. Age and sex matched participants (n=34) with normal kidney function were controls.
Results: CKD patients had significantly (P<0.05) increased F2-isoprostanes and uric acid, and decreased GPx activity compared to controls. When comparing the treatment (atorvastatin, A vs placebo, P) change from baseline to three years, there were no significant differences (P>0.05) in the group difference of the change values: (mean(95%CI), F2-isoprostanes=5.3 (-29.2 to 39.8), protein carbonyls=0.03(-0.13 to 0.19), GPx=-0.10(-4.73 to 4.52), uric acid=8.8(-33.9 to 51.6) or TAC=-0.03(-0.10 to 0.04). A significant difference (P=0.04) in the change in malondialdehyde between groups; 1.52(0.09 to 2.96), was due to a large decrease in the placebo group.
Conclusion: CKD patients had elevated oxidative stress that was not attenuated by atorvastatin 10mg/day for three-years.
|Item Type:||Refereed Article|
|Keywords:||F2-isoprostanes, glutathione peroxidase, malondialdehyde, protein carbonyls, total antioxidant status, uric acid|
|Research Division:||Medical and Health Sciences|
|Research Group:||Clinical Sciences|
|Research Field:||Nephrology and Urology|
|Objective Group:||Clinical Health (Organs, Diseases and Abnormal Conditions)|
|Objective Field:||Urogenital System and Disorders|
|Author:||Robertson, IK (Dr Iain Robertson)|
|Author:||Ball, MJ (Professor Madeleine Ball)|
|Author:||Geraghty, DP (Professor Dominic Geraghty)|
|Year Published:||2015 (online first 2008)|
|Deposited By:||Health Sciences|
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