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β-Amyloid precursor protein: function in stem cell development and Alzheimer's disease brain


Small, DH and Hu, Y and Bolos, M and Dawkins, E and Foa, L and Young, KM, β-Amyloid precursor protein: function in stem cell development and Alzheimer's disease brain, Neurodegenerative Diseases, 13, (2-3) pp. 96-98. ISSN 1660-2854 (2014) [Refereed Article]

Copyright Statement

Copyright 2013 S. Karger AG.

DOI: doi:10.1159/000353686


Stem cell therapy may be a suitable approach for the treatment of many neurodegenerative diseases. However, one major impediment to the development of successful cell-based therapies is our limited understanding of the mechanisms that instruct neural stem cell behaviour, such as proliferation and cell fate specification. The β-amyloid precursor protein (APP) of Alzheimer's disease (AD) may play an important role in neural stem cell proliferation and differentiation. Our recent work shows that in vitro, APP stimulates neural stem or progenitor cell proliferation and neuronal differentiation. The effect on proliferation is mediated by an autocrine factor that we have identified as cystatin C. As cystatin C expression is also reported to inhibit the development of amyloid pathology in APP transgenic mice, our finding has implications for the possible use of cystatin C for the therapy of AD.

Item Details

Item Type:Refereed Article
Keywords:APP, cystatin C, neural stem cells, Alzheimer's disease, amyloid precursor protein, amyloid protein, dementia, mechanism of neurodegenerative diseases, neurodegeneration, protein misfolding
Research Division:Biomedical and Clinical Sciences
Research Group:Neurosciences
Research Field:Cellular nervous system
Objective Division:Expanding Knowledge
Objective Group:Expanding knowledge
Objective Field:Expanding knowledge in the biological sciences
UTAS Author:Small, DH (Professor David Small)
UTAS Author:Hu, Y (Ms Ivy Hu)
UTAS Author:Bolos, M (Dr Marta Bolos Jurado)
UTAS Author:Dawkins, E (Dr Edgar Dawkins)
UTAS Author:Foa, L (Professor Lisa Foa)
UTAS Author:Young, KM (Associate Professor Kaylene Young)
ID Code:100366
Year Published:2014
Web of Science® Times Cited:6
Deposited By:Menzies Institute for Medical Research
Deposited On:2015-05-13
Last Modified:2017-11-06

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