A novel, simple and highly sensitive electrochemical method is developed for the determination of ascorbic acid (AA) and uric acid (UA) based on a palladium nanoparticles deposited on porous graphitized carbon monolith modified carbon paste electrode (PdNPs/CM/CPE). The chemical modified electrode was characterized by scanning electron microscopy (SEM) and electrochemical impedance spectroscopy (EIS). The PdNPs/CM/CPE displayed excellent electrochemical catalytic activities towards AA and UA with bare CPE, PdNPs/CPE, CM/CPE and PdNPs/CM/CPE by cyclic voltammetry (CV). The oxidation potentials of AA and UA at the PdNPs/CM/CPE shifted negatively and the peak currents were much larger than other electrodes. The amperometric signal of PdNPs/CM/CPE showed a good linearity with correlation coefficient greater than 0.997. The low detection limits (S/N = 3) for AA and UA were 0.53 μmol L⁻¹ and 0.66 μmol L⁻¹, respectively. The proposed method showed easy fabrication, high sensitivity and stability, and good reproducibility. In addition, the modified electrode was applied to determine the AA and UA in human serum sample.

Item Type:	Refereed Article
Keywords:	palladium nanoparticles, porous graphitized carbon monolith, ascorbic acid, uric acid, carbon paste electrode
Research Division:	Chemical Sciences
Research Group:	Macromolecular and materials chemistry
Research Field:	Physical properties of materials
Objective Division:	Expanding Knowledge
Objective Group:	Expanding knowledge
Objective Field:	Expanding knowledge in the chemical sciences
UTAS Author:	Nesterenko, PN (Professor Pavel Nesterenko)
UTAS Author:	Paull, B (Professor Brett Paull)
ID Code:	100248
Year Published:	2015
Web of Science® Times Cited:	32
Deposited By:	Chemistry
Deposited On:	2015-05-07
Last Modified:	2017-10-29
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