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Organic solvent and temperature-enhanced ion chromatography-high resolution mass spectrometry for the determination of low molecular weight organic and inorganic anions
Citation
Gilchrist, ES and Nesterenko, PN and Smith, NW and Barron, LP, Organic solvent and temperature-enhanced ion chromatography-high resolution mass spectrometry for the determination of low molecular weight organic and inorganic anions, Analytica Chimica Acta, 865 pp. 83-91. ISSN 0003-2670 (2015) [Refereed Article]
Copyright Statement
Copyright 2015 Elsevier B.V.
DOI: doi:10.1016/j.aca.2015.01.031
Abstract
There has recently been increased interest in coupling ion chromatography (IC) to high resolution mass spectrometry (HRMS) to enable highly sensitive and selective analysis. Herein, the first comprehensive study focusing on the direct coupling of suppressed IC to HRMS without the need for post-suppressor organic solvent modification is presented. Chromatographic selectivity and added HRMS sensitivity offered by organic solvent-modified IC eluents on a modern hyper-crosslinked polymeric anion-exchange resin (IonPac AS18) are shown using isocratic eluents containing 5–50 mM hydroxide with 0–80% methanol or acetonitrile for a range of low molecular weight anions (<165 Da). Comprehensive experiments on IC thermodynamics over a temperature range between 20–45 °C with the eluent containing up to 60% of acetonitrile or methanol revealed markedly different retention behaviour and selectivity for the selected analytes on the same polymer based ion-exchange resin. Optimised sensitivity with HRMS was achieved with as low as 30–40% organic eluent content. Analytical performance characteristics are presented and compared with other IC-MS based works. This study also presents the first application of IC-HRMS to forensic detection of trace low-order anionic explosive residues in latent human fingermarks.
Item Details
Item Type: | Refereed Article |
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Keywords: | ion chromatography, high resolution mass spectrometry, organic solvent, temperature, anions |
Research Division: | Chemical Sciences |
Research Group: | Analytical chemistry |
Research Field: | Separation science |
Objective Division: | Expanding Knowledge |
Objective Group: | Expanding knowledge |
Objective Field: | Expanding knowledge in the chemical sciences |
UTAS Author: | Nesterenko, PN (Professor Pavel Nesterenko) |
ID Code: | 100246 |
Year Published: | 2015 |
Web of Science® Times Cited: | 17 |
Deposited By: | Chemistry |
Deposited On: | 2015-05-07 |
Last Modified: | 2017-10-29 |
Downloads: | 0 |
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